دابوكستين 60 dapoxetine : كم يؤخر دابوكستين القذف؟

This pause allows the patient to acclimatize to the sensation and to condition himself to increased ejaculatory control. This technique helps the patient to heighten his awareness of sexual sensations. Unfortunately, many others have found that any initial success achieved by behavioral therapy was not maintained at 3-year follow-up (Sharlip 2005). MEDLINE and the proceedings of major international and regional scientific meetings during the period 1994–2010 were searched for publications or abstracts using the word dapoxetine in the title, abstract or keywords. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase 1, 2 and 3 efficacy and safety studies and drug-interaction studies.

• The use of SSRIs to treat PE is based on the observation that delayed ejaculation and anorgasmia are common side effects of this class of drugs (41,63).
• The Dapox 30mg tablet offers numerous benefits for men dealing with premature ejaculation, from improving sexual satisfaction and relationship quality to enhancing psychological well-being.
• Both double-blind, multi-center, randomized, placebo-controlled, 3-period cross-over phase II studies enrolled men with PE, based on DSM-IV-TR criteria and IELT.
• Dapoxetine is primarily used in the treatment of sexual dysfunctions like premature ejaculation.
• The pharmacokinetic profile of dapoxetine suggests that it is a good candidate for on-demand treatment of PE.

What are the contraindications of Dapoxetine ?

In the International Study, the incidence of discontinuation syndrome was 3.0%, 1.1% and 1.3% for those continuing to take dapoxetine 30 mg, 60 mg as needed and placebo respectively, and 3.3% for those who switched from dapoxetine 60 mg as needed to placebo Buvat et al. 2009. No subjects switching from dapoxetine 30 mg as needed to placebo in this study showed evidence of the discontinuation syndrome. Dapoxetine is the only SSRI for which these symptoms have been systematically evaluated in a PE population.

Patient Enrollment

DSM-IV TR, Diagnostic and Statistical Manual of Mental Disorders, 4th edition revised; IELT, intravaginal ejaculation latency time. It is the first medicine that has been formulated specifically to treat premature ejaculation. Even though the exact mechanism of action is not known, physicians suspect that it acts by inhibiting the serotonin transporter. The effects of 30 mg dapoxetine generally last for about 1 to 3 hours after taking the dose. However, the duration can vary depending on individual factors such as metabolism and overall health.

Although daily off-label antidepressant SSRI are effective treatments for PE, supportive studies are limited by small study populations, infrequent use of PROs of control, distress and satisfaction as outcome measures and inconsistent reporting of known SSRI class-related safety effects. Currently, dapoxetine has the largest efficacy and safety database for use in men with PE, and it is the only agent for which SSRI class-related effects have been studied in a PE population. Overall, 6,081 men with a mean age of 40.6 years (range, 18–82 years) from 32 countries were enrolled with 4,232 (69.6%) subjects completed their study (Table 2). Dapoxetine is a selective serotonin reuptake inhibitor medicine which has been specially developed for the treatment of premature ejaculation. It increases the time it takes to ejaculate and can improve the control over the ejaculation.

Dosage and Administration

A large body of research indicates that serotonin acting on the brain’s post-synaptic receptors exerts an overall inhibitory control on the ejaculatory process. As far back as 1976, administration of the serotonin (5-Hydroxytryptamine, 5-HT) precursor 5-Hydroxytryptophan was shown to inhibit male rat sexual behavior (15). 5-HT1A receptors have been demonstrated to exert a pro-ejaculatory effect on male sexual behavior. These receptors act on serotonergic neuronal cell bodies as a means of down regulating the release of 5-HT into the https://parumala.designsages.in/peptide-pharmacological-applications-2/ synaptic cleft. Hence, microinjections and a systemic delivery of 8-hydroxy-2-(di-n-propyl-amino) tetralin hydrobromide (8-OH-DPAT), a selective agonist of 5-HT1A receptors, elicits a diminished ejaculatory latency time in rats. There is limited evidence on the function of 5-HT1B and 5-HT2C receptors on ejaculation; however, the studies conducted implicate inhibitory activity for 5-HT1B and 5-HT2C (16,17).